This thesis examines MR1T cells and gamma-delta T cells in early life and how they are shaped by BCG vaccination with the goal of informing how they might be positioned f [...]

The work presented herein advances our understanding of neoplastic-immune hybrid cells as drivers of cancer progression and metastasis. My dissertation studies reveal sh [...]

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes, partly due to dysfunctional vascularization and complex tumor-stromal interactions. Th [...]

This dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifi [...]

This thesis sought to identify and characterize novel drug targets in mycobacteria to aid in the discovery of better treatment options.

The author retains th [...]

This dissertation investigates the molecular link between Parkinson's Disease and melanoma. Specifically, this work presents novel findings showing that alpha-synuclein f [...]

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM s [...]

This dissertation characterizes cross-reactive immunity to emerging alpahviruses such as chikungunya virus in the context of infection or vaccination, in various models.

Work presented in this dissertation describe mechanisms of oligomeric polydispersity and client-binding by various small heat shock proteins (alpha-crystallins, HSP16.5) [...]

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective [...]