This work summarizes a doctoral research project on the role of extracellular vesicles (EVs) in the rare disease Niemann Pick Disease Type C (NPC). It established miRNA e [...]

Pioneer neurons establish the initial nervous system structure by extending axons toward distant targets, but their molecular distinction from follower neurons was previo [...]

Individuals who inherit a pathogenic mutation in SDHA have an increased risk of cancer. However, there is often insufficient evidence to properly assess pathogenicity, an [...]

Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]

We live in a world filled with nearly constant tactile stimuli, and our perceptions of and responses to these stimuli shape our many interactions. Processing the incredib [...]

The greatest risk factor for developing Parkinson's disease is aging, and the accumulation of reactive oxygen species is thought to play a significant role in the aging p [...]

Genetic aberrations that cause constitutive activation of the receptor tyrosine kinase (RTK), ROS1, can drive cancer formation. Treatment of these cancers with tyrosine k [...]

Sympathetic nerves are lost in the damaged myocardium (infarct) after myocardial infarction (MI), and the relative area of denervation predicts risk of sudden cardiac arr [...]

Tendons are an essential tissue that join together and transmit force between muscle and bone. While much is known about muscle and skeletal growth mechanisms, remarkably [...]

The follicle is the structural unit within the ovary where endocrine-acting sex steroids and hormones are synthesized and the development of a mature oocyte capable of be [...]