Department of Biomedical Engineering

The musculoskeletal system includes important structures like muscles and bones that help us move. While minor injuries often heal fully, serious damage can lead to long- [...]

Cell-cell co-occurrence patterns are critical in shaping biological and clinical phenotypes, but existing tools for analyzing single-cell RNA sequencing (scRNA-seq) data [...]

This thesis presents a suite of deep learning frameworks designed to address key challenges in the analysis of Electron Microscopy (EM) images of cancer cells, which are [...]

Tumors overexpressing the HER2 oncogene account for around 20% of breast cancer cases and are associated with aggressive disease. These tumors generally originate from a [...]

Triple Negative Breast Cancer (TNBC) is a complex malignancy subtype which commonly forms aggressive tumors with substantial stromal involvement. Unlike the Luminal and H [...]

Pathological thrombosis is a significant driver of human morbidity and mortality today. Overall, this dissertation presents a study of the pathophysiology, clinical manag [...]

Ossification is a developmental process where bone is created in appositional layers through the gradual calcification of the native extracellular matrix (ECM). This evol [...]

LC8 is a key molecular hub protein involved in a wide array of cellular processes (e.g., apoptosis, viral interactions, signal transduction). LC8 interacts with over 100 [...]

Non-small cell lung cancer (NSCLC) accounts for one in five of all cancer deaths worldwide. Most patients are diagnosed at advanced stages, resulting in a 5-year survival [...]

Cachexia and cancer, when intertwined, precipitate severe adverse outcomes for patients, underscoring the urgent need for innovative therapeutic strategies. This disserta [...]