Department of Chemical Physiology and Biochemistry

This dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifi [...]

This thesis sought to identify and characterize novel drug targets in mycobacteria to aid in the discovery of better treatment options.

The author retains th [...]

ADP-ribosylation is a dynamic post-translational modification predominantly catalyzed by a large family of enzymes called PARPs. PARPs are implicated in diseases such as [...]

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM s [...]

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that modulates dopaminergic transmission. This dissertation describes doctoral research to chara [...]

This dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Thro [...]

The goal of my PhD has been to develop and adapt optical chemical biology approaches to study signal transduction in cells. I developed genetically encoded FRET sensors t [...]

Work presented in this dissertation describe mechanisms of oligomeric polydispersity and client-binding by various small heat shock proteins (alpha-crystallins, HSP16.5) [...]

Marijuana legalization in the United States, both recreationally or medicinally, has increased its use in adults, yet the full impact of cannabinoid molecules found in ma [...]

Poly-(ADP)-ribose polymerases (PARPs) are a family 17 enzymes in humans that have diverse roles in cell biology including innate immune response, DNA repair, and regulati [...]