Color cone opsins are responsible for our daylight and color vision and yet not much is known about them. The goal of the dissertation is to characterize the structure an [...]

This dissertation is focused on the role of post-endocytic sorting in opioid receptor regulation. Specifically, it describes the development of a chemical biology sensor [...]

A barrier in designing safer CB1R drugs is our lack of understanding the circuit and tissue-specific involvement of AEA and THC in different CB1R-mediated pathologies, [...]

P2X receptors are ATP-gated ion channels that play critical roles in physiological and pathophysiological conditions throughout the body. This dissertation elucidates mec [...]

This thesis is structured across three conceptual layers. At the systems level, it examines how pancreatic hormones influence the behavior of native human islets in cultu [...]

This dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It iden [...]

This work explores the structure and function of an important copper monooxygenase: peptidylglycine alpha-amidating monooxygenase. The canonical reaction mechanism of thi [...]

This dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifi [...]

This thesis sought to identify and characterize novel drug targets in mycobacteria to aid in the discovery of better treatment options.

The author retains th [...]

ADP-ribosylation is a dynamic post-translational modification predominantly catalyzed by a large family of enzymes called PARPs. PARPs are implicated in diseases such as [...]