This dissertation presents the development of an improved approach for single-cell whole genome sequencing that achieves the quantitative metrics of gold-standard assays— [...]

The goal of this dissertation is to improve our understanding of the factors governing genetic repair to facilitate whole gene insertion into the genome of mature organis [...]

Current treatments for FTD mitigate some behavioral changes, but there are no therapies that prevent or slow the progression of the disease. Profiling the epigenetic chan [...]

Pancreatic Ductal Adenocarcinoma (PDAc) ranks among the top three most aggressive cancers in the United States and is projected to increase in incidence over the next few [...]

The goal of this dissertation is to improve understanding and treatment for the chorioretinopathy seen in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) p [...]

Liver-directed gene and cell therapies represent a promising therapeutic strategy for many genetic disorders. However, they are hampered by inefficiency. The problem of i [...]

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective [...]

Single-cell technologies have created a new taxonomic challenge: to create a shared language for defining individual cells within complex organisms. In this work, I compl [...]

The loss and/or gain of whole chromosomes, or aneuploidy, that arises during mammalian preimplantation development can lead to embryo arrest, implantation failure, or spo [...]

Ovarian teratoma, comprising cystic mature teratomas and malignant immature teratomas, is a common cancer of the female reproductive tract that tends to occur in young wo [...]