This work summarizes a doctoral research project on the role of extracellular vesicles (EVs) in the rare disease Niemann Pick Disease Type C (NPC). It established miRNA e [...]

Molecular phenotypes, or subtypes, can describe cancer as distinct diseases within primary tissues-of-origin. Machine learning (ML) can be applied to this molecular taxon [...]

Adolescent social isolation is a developmental stressor that increases vulnerability to neuropsychiatric disorders including substance use disorder and eating disorders. [...]

Electronic health records (EHRs) provide a voluminous amount of data for research. However, potential biases threaten the internal and external validity of observational [...]

Acute myeloid leukemia (AML) is a malignancy with a poor survival rate, primarily due to resistance to chemotherapy.Combination therapy using gilteritinib with venetocla [...]

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular [...]

This dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It iden [...]

This dissertation explores the role of emotion regulation in shaping stress and parenting experiences during the perinatal period, focusing on both risk and resilience fa [...]

Androgen hormones regulate the activity of myriad cells of the immune system and are strong drivers of sex differences in disease susceptibility, yet little is known of t [...]

The majority of PDGFRA-mutant gastrointestinal stromal tumors (GIST) harbor exon 18 mutations, most commonly D842V, which is treated with avapritinib (a new type I TKI) b [...]