This dissertation investigates why remyelination becomes inefficient with age in multiple sclerosis (MS) and how this failure drives neuronal loss. Key findings include a [...]

Glial cells are critical for maintaining a healthy nervous system. Key regulatory functions include synaptic remodeling, metabolic support of neurons, and protective immu [...]

This dissertation aims to address how ischemic injury induces cerebrovascular dysfunction and triggers a pathological cycle to accelerate the onset and progression of Alz [...]

Astrocytes are glial cells in the central nervous system that form a vast electrical network connected via gap junctions, called astrocyte syncytium. My thesis focused on [...]

Myelination in the CNS is essential for neuronal function, and oligodendrocytes achieve this by wrapping axons with multilayered myelin sheaths. We identify FBXW7 as a ke [...]

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there are currently no treatments to slow, halt, or reverse the disease process. The diseas [...]