Neuroscience

Myelination in the CNS is essential for neuronal function, and oligodendrocytes achieve this by wrapping axons with multilayered myelin sheaths. We identify FBXW7 as a ke [...]

The cerebellum has traditionally been associated with motor control. However, increasing evidence suggests that it also plays a critical role in cognitive processing. Des [...]

The insular cortex mediates diverse functions, including taste, interoception, decision making, and emotion regulation. However, the cellular and microcircuit mechanisms [...]

The structural and functional characterization of the human bile acid ion channel in the presence and absence of calcium are discussed.

The world is full of sound—often in the form of noisy, acoustically cluttered environments—that we must make sense of. Noise vying for our attention overlaps with the sou [...]

TMEM63B is a newly identified mechanosensor that is found in many dorsal root ganglion neurons. Dorsal root ganglion neurons are responsible somatosensation and one aspec [...]

This dissertation explores the regulation and adaptation of mu-opioid receptors (MORs) within the paraventricular nucleus of the thalamus (PVT), a brain region critical f [...]

When thinking of sodium channels in the nervous system the most notable are voltage gated sodium channels, but a multitude of non-voltage gated channels also contribute t [...]

This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next [...]

Ischemic stroke is the most common type of stroke, accounting for about 87% of all stroke cases. Stroke is a leading cause of long-term disability and the second leading [...]