This dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It iden [...]

ADP-ribosylation is a dynamic post-translational modification predominantly catalyzed by a large family of enzymes called PARPs. PARPs are implicated in diseases such as [...]

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that modulates dopaminergic transmission. This dissertation describes doctoral research to chara [...]

This dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Thro [...]

The goal of my PhD has been to develop and adapt optical chemical biology approaches to study signal transduction in cells. I developed genetically encoded FRET sensors t [...]

Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin angiotensin system (RAS) that acts by degrading angiotensin II (AngII). Within the kidney, ACE2 is [...]

Marijuana legalization in the United States, both recreationally or medicinally, has increased its use in adults, yet the full impact of cannabinoid molecules found in ma [...]

Poly-(ADP)-ribose polymerases (PARPs) are a family 17 enzymes in humans that have diverse roles in cell biology including innate immune response, DNA repair, and regulati [...]

Malaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually decli [...]

Illness behaviors, metabolic disturbances, and cognitive injury are common in cancer patients and frequently lead to wasting or cachexia. This devastating state of malnut [...]