This work explores the structure and function of an important copper monooxygenase: peptidylglycine alpha-amidating monooxygenase. The canonical reaction mechanism of thi [...]

The goal of this research is to characterize the contribution of histidine and methionine to function in copper pro [...]

This dissertation aims to shed light on some of the key questions and lesser known aspects of the mechanism of peptidylglycine alpha-hydroxylating monooxygenase (PHM). [...]

The Blackburn Lab studies biological copper chemistry using biochemical, biophysical, and advanced spectroscopic techniques. Our research aims are two-pronged, which is r [...]

he overarching goal of our research is to better understand the mechanisms by which metalloproteins obtain and transport their target metal ions. We have characterized [...]

Selenocysteine-containing mutants of the human copper chaperone for superoxide dismutase (hCCS) were constructed using intein-mediated peptide ligation to investigate cop [...]

This dissertation describes the structural characterization of peptidylglycine monooxygenase (PHM). PHM belongs to a unique class of enzymes: the mononuclear dicopper m [...]

The human copper chaperone for superoxide dismutase (hCCS) is a multi-domain metalloprotein responsible for delivering copper to cytoplasmic superoxide dismutase (SOD). h [...]