Clathrin mediated endocytosis (CME) is emerging as a critical player in the development and progression of AD in multiple brain cell types. CME is an important intersecti [...]

Chronic stress–driven sympathetic signaling influences cancer development by reshaping the tumor microenvironment (TME). This dissertation reviews how sympathetic nerves [...]

Glial cells are critical for maintaining a healthy nervous system. Key regulatory functions include synaptic remodeling, metabolic support of neurons, and protective immu [...]

Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]

This thesis explores the role of DNA repair enzyme 8-oxoguanine glycosylase (OGG1) in a Drosophila model through both genetic manipulation and the administration of small [...]

Neuronal migration and axonal outgrowth require precise guidance mechanisms during nervous system development. Amyloid precursor protein (APP) has been implicated in thes [...]

The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons tha [...]

This thesis investigates the molecular mechanisms that guide neuronal migration, focusing on Eph receptor–Ephrin signaling in the developing enteric nervous system (ENS) [...]