The overall aim of this work is to understand how biallelic CEBPA mutations block differentiation and contributed to the development of acute myeloid leukemia (AML). This [...]

Dendritic cells (DCs) play a crucial role in mediating immune responses to pathogens and tumors, with their development influenced by signaling from the FLT3 receptor tyr [...]

What properties, at the level of individual molecules, are responsible for allowing the adaptive immune system to differentiate cancerous cells from surrounding healthy t [...]

Identification of druggable mutations in Acute Myeloid Leukemia (AML), such as FLT3-ITD, has led to the development of targeted therapies capable of out-performing cytoto [...]

Generalization, the ability of machine learning models to perform well on new data, remains a major challenge in sensitive fields such as medical settings. This work addr [...]

Leukemias comprise a family of hematologic malignancies characterized by the over-proliferation of myeloid precursor cells. Leukemia development depends on multiple facto [...]

Acute myeloid leukemia (AML) is the most common leukemia in adults and is primarily diagnosed in older patients. The combination of the BCL2 inhibitor, venetoclax, with a [...]