Physical and functional partitioning of the biological membrane have been implicated in regulating heterotypic and homotypic interactions of proteins on the membrane. Amo [...]

Modeling early cellular interactions in the 3D tumor microenvironment is critical to understanding and intercepting early-stage disease, including HER2+ breast cancer. Ho [...]

Most patients with solid tumors do not respond to immune checkpoint blockade, often because their tumors lack sufficient cytotoxic CD8+ T cells. Interleukin-2 (IL-2) can [...]

Super resolution microscopy (SRM) comprises various single-molecule localization techniques that can generate images at the 20 nm scale. In recent years, SRM based on DNA [...]

Cellular function relies on the spatial organization of proteins, and shifts in localization patterns are hallmarks of diseases. Modern proteomics is stead [...]

This thesis work focuses on technical developments in the field of superresolution fluorescence microscopy (SRM) and applications of SRM to probing the spatial organizati [...]

Rat sarcoma viral oncogene homolog (Ras) proteins are important signaling molecules ubiquitously expressed in eukaryotes and are key regulators of normal proliferation an [...]

Articular cartilage is the tissue at the junction of bones where it's highly organized anisotropic structure facilitates its biomechanical function during skeletal motion [...]

A defining characteristics of biological signaling is that it is both robust and versatile: the system can respond to a wide variety of inputs and consistently [...]