Multiple sclerosis (MS) involves immune-mediated demyelination and axonal damage, driven by CD4+ T-cell infiltration across the blood-brain barrier (BBB). This work exami [...]

Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]

Myelin ensheaths axons and increases their conduction velocities. In the central nervous system (CNS) myelin is produced by oligodendrocytes (OLs) that differentiate from [...]

Myelin, produced by oligodendrocytes (OLs), is essential for rapid neural signaling, but is often lost in CNS injuries and diseases like multiple sclerosis (MS). Remyelin [...]

Myelination in the CNS is essential for neuronal function, and oligodendrocytes achieve this by wrapping axons with multilayered myelin sheaths. We identify FBXW7 as a ke [...]