Alphaviruses are arthropod-transmitted RNA viruses, including the NIAID Category B priority pathogens Eastern equine encephalitis (EEEV), Venezuelan equine encephalitis ( [...]

Cytomegalovirus (CMV) establishes lifelong persistence and latency, yet little is known about viral gene expression during these states in vivo. Using a rat heart transpl [...]

This is a basic science project to study the mechanism of a novel, broad-spectrum antiviral small molecule series. The small molecule series, SR-33001, inhibits Herpes, A [...]

Human cytomegalovirus (HCMV) is a pervasive β-herpesvirus that establishes lifelong persistence within the host by adopting a latent state in hematopoietic progenitor cel [...]

Over the last few decades, the utility of viral vectors has expanded from their initial use as clinical therapeutics for debilitating genetic diseases to include their us [...]

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute febrile illness and long-lasting joint and muscle pain. The 2013-2016 CHIKV outbreaks in the Am [...]

Powassan virus is a lethal tick-borne flavivirus currently emerging in North America for which there are no therapies or vaccines. This dissertation focuses on developing [...]

Human cytomegalovirus (HCMV) is a ubiquitous human pathogen associated with numerous inflammatory diseases, including vascular disease in solid organ allografts and certa [...]

This dissertation uses nonhuman primate models to define how emerging arboviruses disrupt placental function and threaten fetal health. Through comparative studies of Zik [...]

Vaccination of rhesus macaques with rhesus cytomegalovirus strain 68-1 expressing SIV proteins (RhCMV/SIV) results in stringent control of SIV replication. Approximately [...]