The hypothalamus plays a key role in maintaining homeostatic functions that change during aging, like reproduction and sleep-wake activity. Using a nonhuman primate anima [...]

This dissertation focuses on brain aging and neurodegeneration, specifically in the context of healthy brain aging versus Alzheimer's disease (AD). To study these process [...]

The growing aging population underscores the need to preserve cognitive health and quality of life. Gonadal and adrenal steroids, including estradiol (E2), testosterone ( [...]

The number of US individuals affected by dementia is expected to rise significantly during the next decade, as the age of the population continues to increase. To this en [...]

Amyloid beta (A?) plaques represent one of the classic hallmarks of Alzheimer's disease (AD) pathology in the brain. In rhesus macaques, these plaques start becoming prom [...]

Transactive response DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed nuclear protein involved in RNA metabolism and stress granule formation. Pathologi [...]

Biological rhythms are essential for maintaining physiological homeostasis, and their disruption is a hallmark of aging. This thesis investigates age-related changes in n [...]