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MR1-restricted T (MR1T) cells are part of a growing class of unconventional T cells that have emerged as important players in the early response to microbial infection. T [...]

Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to inf [...]

Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor ty [...]

Immune checkpoint blockade (ICB) therapy targets checkpoint proteins to restore normal function to the immune system so that it can attack cancer cells. It is used succes [...]

Tissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally [...]

T-cell large granular lymphocytic leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder of mature cytotoxic T-cells. Accurate diagnosis relies on the integrati [...]

Is the capacity of Mtb-specific CD4+ and CD8+ T cells to produce three key Th-1 cytokines compromised among Ugandan children with TB as compared to Ugandan adults with TB [...]

The majority of research on T cells forms a paradigm in which classical T cells are activated by peptide antigens presented by classical MHC molecules. Non-classical T ce [...]