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The goal of this dissertation is to improve our understanding of the factors governing genetic repair to facilitate whole gene insertion into the genome of mature organis [...]

The main focus of this dissertation work was to advance gene therapy research for phenylketonuria (PKU). PKU is an inborn error of metabolism characterized by phenylalani [...]

Colorectal cancer (CRC) is the 3rd most prevalent cancer worldwide. In treating cancer, the tumor microenvironment has a large impact on cell behavior, growth, and tumor [...]