Carnitine palmitoyltransferase I (CPTI) is the rate‑limiting enzyme in mitochondrial fatty acid β‑oxidation and is regulated by malonyl‑CoA. This dissertation investigate [...]

Atrioventricular septal defects (AVSD) are highly heritable, yet their genetic basis remains poorly understood. This study characterizes CRELD1 function using knockout mi [...]

Smad2 and Smad4, but not Smad3, are frequently lost in human skin squamous cell carcinomas (SCCs. Keratinocyte‑specific Smad2 knockout mice showed accelerated tumor forma [...]

Multiple sclerosis (MS) involves both inflammation and neurodegeneration, with mitochondrial dysfunction and oxidative stress playing key roles. Using the EAE mouse model [...]