This dissertation investigates why remyelination becomes inefficient with age in multiple sclerosis (MS) and how this failure drives neuronal loss. Key findings include a [...]

Marijuana legalization across the United States has led to an increase in medical and recreational use in adults. Furthermore, the prevalence of marijuana use in pregnant [...]

Iatrogenic nerve damage remains a significant surgical complication, often resulting in chronic pain, functional loss and decreased quality of life. High resolution fluor [...]

Nearly half of the proteins linked to demyelinating subtypes of Charcot-Marie-Tooth disease regulate endo-lysosomal trafficking. Most of these proteins are expressed in a [...]

Oligodendrocytes are specialized central nervous glia that progress through distinct cellular stages, each with its own specific morphological features, specific proteins [...]

Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of myelin in the central nervous system, resulting in disrupted nerve [...]

Myelin, produced by oligodendrocytes (OLs), is essential for rapid neural signaling, but is often lost in CNS injuries and diseases like multiple sclerosis (MS). Remyelin [...]

Oligodendrocytes, the myelinating glia of the central nervous system, possess P/Q-type voltage-gated calcium channels, but their function has not previously been characte [...]