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This dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifi [...]
2025-04-25 |
Dissertation |
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Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide, with high morbidity, high mortality, and few therapeutic options outside of surgery [...]
2017 |
Dissertation |
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Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in constitutive KIT receptor tyr [...]
2017 |
Dissertation |
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Atherosclerosis is the leading cause of cardiovascular disease, accounting for nearly 30% of deaths in the United States. Patients with late-stage atherosclerosis suffer [...]
2022 |
Dissertation |
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Protein tyrosine kinases play an essential role within cells, transmitting signals to propagate a variety of fundamental cell functions. The activity of tyrosine kinases [...]
2003-06-01 |
Dissertation |
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