Acid‑sensing ion channels are sodium‑selective channels gated by extracellular protons and are known to play a role in sensing ischemic conditions. Ischemia occurs when a [...]

Respiratory viral infections trigger asthma exacerbations, yet the acute effects of Toll-like receptor 7 (TLR7) signaling on airway physiology are poorly understood. This [...]

Benzodiazepine receptor agonists (BZRA), which include brand names such as Valium, Xanax and Ambien, have been prescribed in clinical practice for decades. Despite their [...]

Opioids are highly effective analgesics but frequently lead to tolerance and dependence. Opioid effects are mediated by the μ‑opioid receptor (MOR), whose regulation thro [...]

MR1-restricted T (MR1T) cells are part of a growing class of unconventional T cells that have emerged as important players in the early response to microbial infection. T [...]

Androgen hormones regulate the activity of myriad cells of the immune system and are strong drivers of sex differences in disease susceptibility, yet little is known of t [...]