Actin crosslinkers help shape the structure and mechanics of hair cell stereocilia. We identified several abundant crosslinkers and examined the developmentally regulated [...]

Brain ischemia triggers a two‑phase response that ultimately leads to neuronal injury. While much research has focused on the severe ionic disruption of the late phase, e [...]

Sensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensi [...]

Sensory adaptation in inner ear hair cells depends on myosin‑1c (Myo1c), the molecular motor that regulates mechanotransduction channel sensitivity. This dissertation exa [...]

Signal transduction entails the precise interaction of relevant proteins for transmission of signaling pathways that carry out essential functions. In cancer, dysregulate [...]

Regulated transport of intracellular cargo by molecular motor proteins is essential for cellular organization, particularly in polarized cells such as neurons, yet the me [...]