Amyotrophic Lateral Sclerosis is the most common adult onset motor neurodegenerative disease. The etiology of the disease remains obscure, and as such there is no effecti [...]

Purkinje cells are key regulators of motor coordination, and disruptions in their regular firing patterns contribute to cerebellar ataxias. This thesis examines how alter [...]

Obesity is a global health concern linked to chronic diseases such as diabetes, hypertension, and cancer, yet its underlying mechanisms remain unclear. Conjugated linolei [...]

Synaptic transmission is a process through which neurotransmitter is released from vesicles and triggers a subsequent postsynaptic voltage change. Such interneuronal comm [...]

Endogenous cannabinoids, such as anandamide (AEA), have multiple important functions in the brain including modulation of the reward response and neuroplasticity. There a [...]

Long-term potentiation (LTP) relies on coordinated kinase activity, including CaMKII and ERK, to regulate synaptic strength through AMPA receptor function and trafficking [...]

Voltage gated calcium channels (VGCCs) allow for depolarization-induced calcium entry into neurons and are crucial regulators of neuronal signal transduction. Ongoing wor [...]