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Immune checkpoint blockade (ICB) therapy targets checkpoint proteins to restore normal function to the immune system so that it can attack cancer cells. It is used succes [...]

Colorectal cancer (CRC) is the 3rd most prevalent cancer worldwide. In treating cancer, the tumor microenvironment has a large impact on cell behavior, growth, and tumor [...]

Interferon regulatory factor 6 plays a significant role in the regulation of intestinal epithelial cell identity, interferon response, and apoptosis.

LC8 is a key molecular hub protein involved in a wide array of cellular processes (e.g., apoptosis, viral interactions, signal transduction). LC8 interacts with over 100 [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

Non-small cell lung cancer (NSCLC) accounts for one in five of all cancer deaths worldwide. Most patients are diagnosed at advanced stages, resulting in a 5-year survival [...]