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The PC12 cell line is a well‑established model for studying nerve growth factor (NGF)–dependent neuronal differentiation, characterized by cell cycle exit and neurite out [...]
2008 | Dissertation |
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In this dissertation, the discovery of the first CSF2RB-activating human variant found in the germline of a pediatric T-cell acute lymphoblastic leukemia patient is pres [...]
2017 | Dissertation |
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Cancer is now the biggest single cause of mortality worldwide, incidence has increased by 11% in four years and cases are forecast to rise by 75% over the next 20 years. [...]
2017 | Dissertation |
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HER2-positive breast cancer is an aggressive subtype of breast cancer with patients having significantly lower survival rates compared to other breast cancers. HER2-posit [...]
2014 | Dissertation |
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Understanding gene regulation is critical for developing novel therapeutic strategies. This study presents a new method for generating human cell lines that function as r [...]
2007 | Thesis |
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LAVA (LINE-Alu-VNTR-Alu-like) elements are non-autonomous retrotransposons specific to gibbons and may have influenced their evolution. These elements contain segments fr [...]
2016-12-01 | Capstone |
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Methamphetamine (METH) disrupts dopamine (DA) homeostasis through interactions with the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). This stu [...]
2006 | Dissertation |