Here, I present a comprehensive assay termed UbiReal for monitoring each step of the Ub signaling cascade, including linkage-specific polyUb ligation and deubiquitination [...]

Acid-sensing ion channels (ASICs), initially thought to gate solely via proton binding, have been shown to activate through pH-independent mechanisms, revealing diverse r [...]

Neurons, information-processing units of the human brain, are polarized cells that have a soma, tentacle-like dendrites and a typically tubular axon. For infor [...]

Ion‑coupled secondary transport enables concentrative uptake of diverse molecules across membranes and is exemplified by LeuT, a bacterial homolog of the Neurotransmitter [...]