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Viruses within the Herpesviridae family are encapsulated, enveloped, double-stranded DNA viruses, with large coding potentials that have co-evolved with their hos [...]
2016-04-01 |
Dissertation |
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Adeno-associated virus (AAV) based in vivo gene therapy has made great progress in recent years including an approved treatment (Glybera) in Europe and several [...]
2016-04-01 |
Dissertation |
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Adeno-‐associated virus (AAV) is a leading candidate as a gene therapy vector, but as with other vectors, one of the limitations is a host-neutralizing immune response.
2012-05-01 |
Dissertation |
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This dissertation describes the development of the TRADE system for directed evolution of the AAV capsid, its successful application to identify the HN1 variant, a novel [...]
2021 |
Dissertation |
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