Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a marked propensity for liver metastasis and a poor overall prognosis. Although canonical d [...]

Aberrant epigenetic silencing is a major mechanism of tumor suppressor gene inactivation, yet the early events that trigger this process are not well defined. This work d [...]

The brain is highly sensitive to disruptions in homeostasis caused by hypoxia, ischemia, or excitotoxicity, yet it can activate endogenous neuroprotective mechanisms. Thi [...]

Identification of biologically relevant high-occupancy transcription factor binding sites (TFBS) in silico has historically been a difficult problem with a high error rat [...]

A large body of evidence shows that prolonged stress or even a single traumatic experience can lead to neurobiological and behavioral changes that are persistent. These c [...]

Acute Myeloid Leukemia (AML) is the most common acute adult leukemia, accounting for approximately 1% of all new cancers in 2018. DNA methylation is an epigenetic modific [...]

Embryonic stem cells (ESCs) maintain pluripotency through core factors such as Nanog, yet downstream epigenetic mechanisms remain unclear. This study identifies Kdm5b, an [...]

According to the American Diabetes Association, approximately 30 million Americans were diagnosed with diabetes as of 2012, representing over ten percent of the populatio [...]