Adult liver progenitor cells are biliary-like epithelial cells that emerge only under injury conditions in the periportal region of the liver. They exhibit phenotypes o [...]

Interferon (IFN) family cytokines stimulate a broad group of genes known as interferon stimulated gene (ISGs). The primary function of ISGs is to provide antiviral host d [...]

This dissertation addresses the urgent clinical need to develop and identify blood-based biomarkers for cancer that can help avoid unnecessary surgeries for benign masses [...]

This thesis describes fibroblast growth factor signaling in the development of resistance to tyrosine kinase inhibitor therapy in solid and hematologic malignancies, and [...]

Interferon lambda is critical for host viral defense at mucosal surfaces and contributes unique immunomodulatory effects primarily in epithelial cells. Although expressed [...]

Our ability to therapeutically manage breast tumors has been revolutionized by the use of drugs targeting the activity of the estrogen and HER2 receptors. However, the ef [...]

Tumor-initiating cells (TICs) drive tumor formation and may contribute to metastasis. Using a mouse model of squamous cell carcinoma (SCC), we identified two TIC populati [...]

Cachexia and cancer, when intertwined, precipitate severe adverse outcomes for patients, underscoring the urgent need for innovative therapeutic strategies. This disserta [...]