Metastatic spread of disease accounts for the overwhelming majority of cancer-­related deaths, as current therapies are largely ineffective in treatin [...]

Cachexia is a devastating metabolic syndrome affecting up to 80% of patients with pancreatic ductal adenocarcinoma. Cardiac wasting and injury are common manifestations, [...]

The mammalian brain is supplied with blood by specialized vasculature that is structurally and functionally distinct from that of the periphery. A defining feature of th [...]

Salmonella enterica serotype Typhimurium is a Gram-negative facultative intracellular bacterium that causes a typhoid-like disease in mice. Salmonella invades the gut epi [...]

Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pa [...]

Sepsis is a life‑threatening inflammatory response to infection and remains a major clinical challenge. Although sepsis causes widespread immune dysfunction and eosinopen [...]