Methamphetamine-associated heart failure (MethHF) is quickly becoming a recognized healthcare problem with devastating patient and societal impact, especially in the stat [...]

This dissertation demonstrates that engineered collagen-based microenvironments can be designed to improve craniofacial bone regeneration by integrating matrix mechanics, [...]

The extracellular matrix (ECM) plays a governing role in regulating functional cell and tissue behavior through biochemical and biophysical signaling. Ongoing tissue engi [...]

TMEM63B is a newly identified mechanosensor that is found in many dorsal root ganglion neurons. Dorsal root ganglion neurons are responsible somatosensation and one aspec [...]

Sensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensi [...]

Zebrafish serve as a key model for auditory and vestibular research. We developed a novel method to quantify vestibular defects in larvae using the vestibulo-ocular refle [...]

This interview with Dr. Peter Barr-Gillespie explores his scientific and administrative career. Barr-Gillespie recounts his early interest in science, beginning with chem [...]

Inner ear hair cells are critical for our senses of hearing and balance. Mechanotransduction happens in the hair bundle, a unique sub-cellular organelle of the hair cells [...]

The use of synthetic mRNA-based gene modification offers several advantages over traditional DNA based gene therapy including faster translational kinetics, transient exp [...]

Mechanosensation in hair cells relies on precise protein trafficking and specialized structures for proper function. Using zebrafish models, this work examines the role o [...]