One of the most important tools for diagnosis, analysis, and study of cancer tissues is immunolabeling. Simultaneously analyzing both expression and spatial data of key s [...]

Adoptive T cell immunotherapy has shown significant promise in advanced melanoma, with over half of patients who failed standard treatments achieving objective clinical r [...]

Mechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and [...]

Oregon has one of the highest incidence rates of melanoma in the country. Despite the preventable nature of melanoma, there is no formal statewide, high school-based educ [...]

Tissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally [...]

Shared decision-making integrates patient values with clinical evidence and is paramount in patient-doctor collaboration. Dermatology is especially appropriate for such c [...]

Cancer treatment has advanced rapidly in the past decade, with checkpoint inhibitors (CPIs) delivering improved outcomes across a variety of malignant indications. Howeve [...]

The incidence of malignant melanoma has risen substantially in the United States over recent decades, with solar ultraviolet (UV) radiation recognized as a key causal fac [...]

This dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Thro [...]