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Digital scan of a 35mm slide. Side-by-side comparison of two electron microscope images of surfaces of artificial heart valves labeled A 70X-S and B 10X-S.

Digital scan of a 35mm slide. Side-by-side comparison of two electron microscope images of surfaces of artificial heart valves labeled A 550x-D and B 19X-D.

This thesis presents a suite of deep learning frameworks designed to address key challenges in the analysis of Electron Microscopy (EM) images of cancer cells, which are [...]

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM s [...]

Structural biology is ultimately the study of particular domains and residues, but this knowledge most interesting and useful in the con-text of physiological processes. [...]

The pancreatic β-cell is responsible for producing and secreting insulin, a critical hormone which keeps blood glucose within a narrow physiological ran [...]

When thinking of sodium channels in the nervous system the most notable are voltage gated sodium channels, but a multitude of non-voltage gated channels also contribute t [...]

The epithelial sodium channel (ENaC) is expressed at the apical side of epithelial cells and is a key regulator of salt and water balance. By serving as the rate-limiting [...]

As a part of the Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) precision medicine cancer trial, serial biopsies from cancer patients ar [...]

Intercellular communication by the gap junctions is facilitated by a unique macromolecular architecture, in which transmembrane channels directly couple the plasma membra [...]