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This dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifi [...]

Super resolution microscopy (SRM) comprises various single-molecule localization techniques that can generate images at the 20 nm scale. In recent years, SRM based on DNA [...]

This thesis describes fibroblast growth factor signaling in the development of resistance to tyrosine kinase inhibitor therapy in solid and hematologic malignancies, and [...]

Successful cancer treatment continues to elude modern medicine and its arsenal of therapeutic strategies. Therapy resistance is driven by tumor heterogeneity, complex int [...]

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide, with high morbidity, high mortality, and few therapeutic options outside of surgery [...]

Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in constitutive KIT receptor tyr [...]

The majority of gastrointestinal stromal tumor (GIST) are driven by mutations in KIT or platelet derived growth factor receptor alpha (PDGFRA) receptor tyrosine kinases. [...]

This thesis work focuses on technical developments in the field of superresolution fluorescence microscopy (SRM) and applications of SRM to probing the spatial organizati [...]