MR1-restricted T (MR1T) cells are part of a growing class of unconventional T cells that have emerged as important players in the early response to microbial infection. T [...]

In the absence of a prophylactic vaccine and curative strategies, the daily use of antiretroviral therapy (ART) is essential for preventing and maintaining HIV infection. [...]

The majority of research on T cells forms a paradigm in which classical T cells are activated by peptide antigens presented by classical MHC molecules. Non-classical T ce [...]

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of myelin in the central nervous system, resulting in disrupted nerve [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

CD4 T cell effector functions are critical for protective immunity but can also drive pathological inflammation. The costimulatory receptor OX40 (CD134) enhances CD4 T ce [...]

CD4 T cells play complex roles in cancer immunotherapy, acting as both enhancers and suppressors of anti-tumor immunity. This study examined tumor-specific CD4 T cells in [...]

This thesis is composed of two studies that utilizes different statistical methods to answer cancer research questions. The first study uses supervised and unsupervised s [...]

This thesis examines MR1T cells and gamma-delta T cells in early life and how they are shaped by BCG vaccination with the goal of informing how they might be positioned f [...]