Novel anti-CB1 monoclonal antibodies, including an N-terminal binding antibody, were characterized and validated. These antibodies were then used to investigate the role [...]

Human cytomegalovirus (HCMV) is a pervasive β-herpesvirus that establishes lifelong persistence within the host by adopting a latent state in hematopoietic progenitor cel [...]

This dissertation describes my work on two main projects, first to expand and calibrate a site-directed fluorescence labeling method that can assess distance relationshi [...]

The visual transduction system provides a model for GPCR signaling and inactivation, where rhodopsin activation is quenched through retinal release, photoproduct conversi [...]

G protein-coupled receptors (GPCRs) mediate essential transmembrane signaling, requiring precise attenuation by regulatory proteins. This work examines interactions betwe [...]

G protein-coupled receptors (GPCRs) play an essential role in signal transduction by transmitting extracellular stimuli into intracellular responses through activation of [...]

Information is transmitted between neurons through a process known as synaptic transmission. We are resolved to study synaptic transmission as an effort to understand t [...]

This work investigates how mutant gonadotropin‑releasing hormone receptors (GnRHRs) contribute to disease by altering receptor trafficking and function. Epitope tagging w [...]

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that modulates dopaminergic transmission. This dissertation describes doctoral research to chara [...]