Nicotine and ethanol are frequently co-abused, yet the mechanisms underlying this association remain unclear. This dissertation examined combined versus independent effec [...]

This study examined the fasting response of Native Alaskan children homozygous for the CPT1A c.1436C→T variant, which reduces hepatic fatty acid oxidation. Five children [...]

Drug abuse is influenced by genetic and environmental factors, and acute drug‑induced locomotor responses serve as useful endophenotypes. This dissertation investigates t [...]

Drug abuse poses significant harm to individuals and families and places a heavy burden on societal resources. Because treatment outcomes for drug dependence remain incon [...]

Slow channel syndrome (SCS) is a congenital myasthenic disorder caused by mutations in nicotinic acetylcholine receptor (AChR) subunits, prolonging channel openings and i [...]