Aberrant epigenetic silencing is a major mechanism of tumor suppressor gene inactivation, yet the early events that trigger this process are not well defined. This work d [...]

Cancer remains the second leading cause of death in the United States, despite recent declines in mortality. Tumor progression involves evading cellular checkpoints, incl [...]

This study investigates the role of p73 in epidermal carcinogenesis and DNA damage responses within the context of p53 family signaling. Loss of p73 promoted malignant co [...]

The MDM2–p53 feedback loop is tightly regulated to restrain inappropriate p53 activation while allowing rapid cellular stress responses. This dissertation investigates re [...]

This study identifies SCFβTrCP1 as an E3 ubiquitin ligase that selectively stabilizes and activates the TAp63γ isoform. βTrCP1 increases TAp63γ protein levels and half-li [...]

c-Myc is a potent oncogenic transcription factor essential for normal development and frequently overexpressed in human cancers. As a member of the Myc family, c-Myc regu [...]