This dissertation examines how TAAR1 functionality influences dorsal raphe serotonin neuron activity, glutamatergic inputs, and methamphetamine (MA) intake in mice with d [...]

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM s [...]

Tight regulation of the proliferative status of intestinal stem cells is critical for establishing a functional epithelial layer during development, a homeostatic state i [...]

Marfan Syndrome is a genetic condition defined by autosomal dominant variations in the FBN1 gene resulting in changes to the cardiovascular, ocular, and skeletal systems. [...]

The mutational status of platelet-receptor PEAR1 was recently identified as a major factor for survival of young patients with Acute Myeloid Leukemia. While studies show [...]

The intricate regulation of transcriptional programs and DNA replication processes in mammalian cells relies on dynamic nuclear protein organization. Our findings reveale [...]

Chronic Neutrophilic Leukemia (CNL) is a myeloproliferative neoplasm characterized by an overproduction of mature neutrophils. In over 90% of CNL cases, patients present [...]

This dissertation focuses on studying familial platelet disorder and underlying mechanisms through which RUNX1 mutations impact the function of stem cells