Is the capacity of Mtb-specific CD4+ and CD8+ T cells to produce three key Th-1 cytokines compromised among Ugandan children with TB as compared to Ugandan adults with TB [...]

Immune checkpoint blockade (ICB) therapy targets checkpoint proteins to restore normal function to the immune system so that it can attack cancer cells. It is used succes [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to inf [...]