Non-small cell lung cancer (NSCLC) accounts for one in five of all cancer deaths worldwide. Most patients are diagnosed at advanced stages, resulting in a 5-year survival [...]

Long-chain 3-Hydroxyacyl CoA Dehydrogenase Deficiency (LCHADD) is an autosomal recessive defect in fatty acid oxidation that presents with hypoketotic hypoglycemia and/or [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

Colorectal cancer (CRC) is the 3rd most prevalent cancer worldwide. In treating cancer, the tumor microenvironment has a large impact on cell behavior, growth, and tumor [...]

Interferon regulatory factor 6 plays a significant role in the regulation of intestinal epithelial cell identity, interferon response, and apoptosis.

Immune checkpoint inhibitor (ICI) therapies, such as anti-PD1 and anti-CTLA4, have proved to be clinically effective in numerous malignant diseases due to their ability t [...]