PGRP3 is a protein that helps the body recognize and respond to bacteria based on the essential structures of the bacteria. They are believed to act by helping to maintai [...]

This dissertation uncovers how PARP7 regulates transcription and innate immune signaling, with a focus on its suppression of type I interferon (IFN-I) expression. It iden [...]

PARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a pr [...]

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of malignancies, with a dismal survival rate and limited treatment options. Advances in therapeutic modalit [...]

ADP-ribosylation is a dynamic post-translational modification predominantly catalyzed by a large family of enzymes called PARPs. PARPs are implicated in diseases such as [...]

In the absence of a prophylactic vaccine and curative strategies, the daily use of antiretroviral therapy (ART) is essential for preventing and maintaining HIV infection. [...]