The goal of this dissertation is to improve our understanding of the factors governing genetic repair to facilitate whole gene insertion into the genome of mature organis [...]

This dissertation investigates the molecular link between Parkinson's Disease and melanoma. Specifically, this work presents novel findings showing that alpha-synuclein f [...]

Pancreatic Ductal Adenocarcinoma (PDAc) ranks among the top three most aggressive cancers in the United States and is projected to increase in incidence over the next few [...]

Individuals who inherit a pathogenic mutation in SDHA have an increased risk of cancer. However, there is often insufficient evidence to properly assess pathogenicity, an [...]

Neuropathy Target Esterase (NTE) is an enzyme localized to the ER that regulates Protein Kinase A (PKA) signaling and maintains lipid homeostasis. Exposure to a neurotox [...]