The ability of tumors to induce immunosuppression and inhibit the cytolytic function of tumor-infiltrating lymphocytes (TIL) is a major obstacle to creating effective imm [...]

Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]

Monoclonal antibodies targeting key receptors that inhibit T cell function such as CTLA-4 and PD-1 have demonstrated the potency of checkpoint blockade, highlighted by lo [...]

The inability to develop an effective anti-tumor immune response plays a key role in cancer progression. Patients with a strong anti-tumor T cell response, indicated by i [...]

The majority of research on T cells forms a paradigm in which classical T cells are activated by peptide antigens presented by classical MHC molecules. Non-classical T ce [...]

Vaccination of rhesus macaques with rhesus cytomegalovirus strain 68-1 expressing SIV proteins (RhCMV/SIV) results in stringent control of SIV replication. Approximately [...]