The abnormal accumulation of the intracellular protein a-synuclein has been implicated in the pathogenesis of several neurodegenerative disorders, including Dementia with [...]

This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next [...]

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there are currently no treatments to slow, halt, or reverse the disease process. The diseas [...]

This dissertation investigates the molecular link between Parkinson's Disease and melanoma. Specifically, this work presents novel findings showing that alpha-synuclein f [...]

Exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) is a recently elaborated pathway by which solutes are trafficked into and out of the brain. This pathw [...]

Lewy bodies comprised of aggregated alpha synuclein (αSyn) protein are a pathological hallmark of the Parkinson's disease (PD). Increased oxidative stress, mitochondrial [...]

Tauopathy and a-synucleinopathy often occur together in human brain diseases but most commonly in the context of B-amyloidosis. Tauopathy induced by a-synucleinopathy in [...]

Parkinson’s disease (PD) is responsible for more balance and cognitive disability than most chronic diseases. Cognitive function, mainly executive function, is essentia [...]

Individuals with Parkinson Disease (PD) often present with hypokinetic dysarthria which can impact intelligibility, ability to communicate with friends and family, and pa [...]

Exercise interventions can improve mobility in people with Parkinson's disease (PD). Recently, it has been shown that an Agility Boot Camp intervention with Cognitive Cha [...]