Sensory hair cells adapt to sustained mechanical stimulation through Ca²⁺-dependent closure of transduction channels via fast and slow mechanisms. Using genetically sensitized mouse models, this study examined the roles of myosin-1c (Myo1c) and myosin-7a (Myo7a) in hair-cell adaptation. Pharmacological inhibition of Myo1c blocked both fast and slow adaptation in vestibular hair cells, indicating a mechanical role for Myo1c in both processes. Studies of Myo7a suggest it is essential for proper transduction and bundle organization, highlighting distinct myosin contributions to hair-cell adaptation and auditory function.
