Prostate-specific antigen (PSA)-based prostate cancer screening recommendations are going through drastic changes. The U.S. Preventive Task Services 2017 (current draft recommen-dation), American Cancer Society 2016, and National Comprehensive Cancer Network 2016 have updated their recommendations to include a shared decision-making (SDM) process for men when they are considering PSA testing. To ensure that the recommendations are followed in clinical practice, patient decision aids (PSA-PtDAs) are one strategy to support SDM. However, the effect of the PSA-PtDAs on men’s intention to undergo PSA testing remains unclear. The purpose of this systematic review and meta-analysis was to answer the following key questions: (1) how do PSA-PtDAs compared with usual care affect men’s prostate cancer screening behavior and (2) are com-puter-based interactive PSA-PtDAs more influential in changing men’s screening intention than other types of decision aids?