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Abstract
Prenatal overnutrition due to maternal obesity or diabetes can induce metabolic and physiologic changes in the fetus that increase the child’s risk of developing cardiovascular disease later in life. These changes may also alter the child’s physiological response to physical activity. However, few studies have explored the potential interaction between prenatal overnutrition and offspring physical activity as determinants of cardiovascular health. In this project we aimed to determine the extent to which children who experienced prenatal overnutrition are more sensitive to the harmful effects of physical inactivity on developing cardiovascular disease later in life.