Opioid analgesic drugs prescribed for pain have the potential for misuse and addiction. In 2011, dentists prescribed 12% of the total prescriptions written in the United States for immediate release opioids, particularly hydrocodone and oxycodone. In October 2014, a federal mandate reclassified hydrocodone combination products as Schedule II drugs requiring a written prescription. Reclassification assumed a subsequent change in provider prescribing habits. The aim of this study was to evaluate the opioid prescribing practices and the impact of the federal mandate on prescribing at the Graduate Endodontic Clinic, Oregon Health & Sciences University (OHSU) School of Dentistry.